The Role of Regulatory T Cells in Immune Tolerance and Inflammatory Diseases

Abstract

Regulatory T cells (Tregs) are crucial for the maintenance of immune tolerance, ensuring that

the immune system does not attack self-antigens and thereby preventing autoimmune

diseases. These cells play a central role in regulating the immune response, balancing

immune activation and suppression. Recent research has highlighted the importance of Tregs

in both immune homeostasis and inflammation, particularly in inflammatory diseases. This

paper explores the role of Tregs in immune tolerance and their involvement in various

inflammatory conditions. The mechanisms by which Tregs suppress immune responses, their

interactions with other immune cells, and the consequences of Treg dysfunction in

inflammatory diseases are discussed. Additionally, potential therapeutic strategies targeting

Tregs for the treatment of autoimmune and inflammatory disorders are explored.