Immunosenescence: Mechanisms of Immune Aging and Its Impact on Disease Susceptibility

Abstract

Immunosenescence refers to the gradual deterioration of the immune system associated with

aging, characterized by changes in immune cell function, a decrease in immune

responsiveness, and a predisposition to chronic diseases and infections. This paper explores

the underlying mechanisms of immune aging, including alterations in immune cell

composition, signaling pathways, and the influence of chronic inflammation (inflammaging).

The consequences of immunosenescence on disease susceptibility, particularly in older

adults, are also examined. The discussion highlights the importance of immunosenescence in

the pathogenesis of diseases such as infections, autoimmune disorders, cancer, and

cardiovascular diseases, with a focus on the potential strategies for mitigating these effects.

Research findings from recent studies are reviewed, suggesting avenues for future

interventions aimed at rejuvenating the immune system and improving health outcomes in

aging populations.