Innate Immunity in Autoimmunity: New Insights into the Role of Pattern Recognition Receptors

Abstract

Autoimmune diseases represent a diverse group of disorders where the immune system

mistakenly attacks the body’s own cells and tissues. While adaptive immunity is typically

recognized as the primary driver of autoimmunity, emerging research has highlighted the

significant role of innate immunity, particularly the involvement of pattern recognition

receptors (PRRs), in the pathogenesis of these diseases. This paper explores the mechanisms

through which PRRs contribute to autoimmunity, focusing on their role in recognizing

endogenous and microbial-associated molecular patterns, activation of inflammatory

pathways, and the potential therapeutic implications. Insights into the intersection of innate

immune responses and autoimmunity are crucial for developing novel treatment strategies for

autoimmune diseases.