Innovations in Orthobiologics: Platelet-Rich Plasma and Bone Morphogenetic Proteins in Musculoskeletal Healing

Abstract

Orthobiologics, a rapidly evolving field in musculoskeletal medicine, incorporates biologic

agents like Platelet-Rich Plasma (PRP) and Bone Morphogenetic Proteins (BMPs) to promote

healing and regeneration of musculoskeletal tissues. This paper reviews the mechanisms,

clinical applications, and current research on PRP and BMPs in the context of

musculoskeletal healing. Platelet-rich plasma has gained traction for its role in accelerating

healing by delivering growth factors that aid tissue repair, while bone morphogenetic proteins

are instrumental in bone regeneration and repair. Both therapies have shown promising

results in treating tendon, ligament, cartilage, and bone injuries. However, their use is still

subject to ongoing research, with challenges related to standardization and regulatory

approval. This paper aims to summarize these advances and provide insights into their future

potential in clinical settings.