The Role of Fecal Microbiota Transplantation in Treating Clostridium difficile Infection and Beyond
Keywords:
Fecal Microbiota Transplantation, Clostridium difficile infection, gut microbiome, antibiotic resistance, microbiome-based therapies, gastrointestinal health, clinical outcomes.Abstract
Fecal microbiota transplantation (FMT) has emerged as an effective treatment option for
Clostridium difficile infection (CDI), a debilitating gastrointestinal disease primarily caused
by antibiotic disruption of the gut microbiome. This paper explores the role of FMT in
treating CDI and its broader potential in treating various other gastrointestinal and systemic
disorders. By analyzing the current literature, the paper presents the mechanisms by which
FMT restores a healthy microbiome, outlines its clinical efficacy in treating CDI, and
investigates its use in other conditions, including inflammatory bowel disease (IBD), irritable
bowel syndrome (IBS), and metabolic disorders. Despite promising outcomes, challenges
such as standardization, long-term safety, and regulatory issues remain. This paper concludes
by discussing future directions in microbiome-based therapies and the need for further
clinical trials to refine FMT’s therapeutic potential.
