Ototoxicity and Hearing Loss: Mechanisms, Prevention, and Therapeutic Approaches in Cancer Treatment
Keywords:
Ototoxicity, hearing loss, cancer treatment, chemotherapy, platinum-based agents, cochlea, prevention, therapeutic approaches, auditory system, gene therapy, cochlear implants.Abstract
Ototoxicity, induced by various chemotherapeutic agents, is a significant concern in cancer
treatment, leading to hearing loss in many patients. This paper reviews the mechanisms by
which ototoxic drugs affect the auditory system, the challenges associated with preventing
hearing loss, and the therapeutic approaches that are currently being developed or
implemented. Ototoxic drugs, including platinum-based chemotherapies and certain
antibiotics, can cause damage to the cochlea and auditory pathways, often resulting in
permanent hearing impairment. Understanding these mechanisms has led to the exploration
of preventive strategies, such as the use of protective agents, dose modifications, and novel
drug delivery techniques. Furthermore, advancements in gene therapy and cochlear implants
hold promise for mitigating the impact of ototoxicity. This paper concludes with an emphasis
on the need for integrated strategies to protect auditory function while ensuring the efficacy
of cancer treatment.
