Exploring the Genetic Underpinnings of Coronary Artery Disease: Implications for Personalized Medicine

Abstract

Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide.

Understanding the genetic factors contributing to CAD is critical for advancing both

diagnostic and therapeutic strategies. This paper reviews the current literature on the genetic

underpinnings of CAD, exploring key genetic loci and their implications for personalized

medicine. It discusses genome-wide association studies (GWAS), the role of single

nucleotide polymorphisms (SNPs), and the potential for genetic testing in clinical settings.

Additionally, the paper explores how personalized medicine, informed by genetic data, can

improve the prevention, diagnosis, and treatment of CAD, ultimately leading to better patient

outcomes. The integration of genetic insights into clinical practice has the potential to

transform CAD management, but challenges related to ethical considerations, cost, and

accessibility remain. This review underscores the promise of genetic research in CAD and

highlights the need for ongoing studies to refine and validate these findings.